Delinquent disease that affects the outer and inner conscious and unconscious motivations crime is committed. And hence in need of correction and treatment some deviations and crimes are being committed by people with mental disorders. These people are a bunch of people with major depression. Criminologists found to provide a thorough study of crime and deviance at the same time or inclination to investigate organized crime and crime situation before payment. Field research method was causal-comparative method to predict the impact of depressive illness major relationship with attitude toward drug. To this end, 40 people were tested in Behbahan city. Subjects were 20 patients with major depression and 20 normal matched, 10 male and 10 female. To check out questionnaires to examine attitudes towards drugs, the two groups were used. Data obtained through descriptive statistics, frequency and percentage and inferential statistics (chi-square test) were analyzed. The results showed: in terms of attitudes towards drugs among individuals with major depression, the general attitude, emotions, beliefs and readiness to act against drug abuse, there is a significant difference compared to normal individuals. This means that depressed people are more vulnerable.